...

100) McCarter FD, James JH, Luchette FA, Wang L, Friend LA, King JK, Evans JM, George MA, Fischer JE: Adrenergic blockade reduces skeletal muscle glycolysis and Na(+), K(+)-ATPase activity during hemorrhage. J Surg Res. 99: 235-44, 2001
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101) James JH, F.A.Luchette, F.D.McFischer & J.E.Fischer (Cincinatti / USA): Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 354: 505-508, 1999
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102) Luchette FA, Robinson BR, Friend LA, McCarter F, Frame SB, James JH (Cincinatti /USA): Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. J Trauma. 46: 873-80, 1999
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103) Greenberger NJ, Richard P.MacDermott, James F.Martin & Saradindu Dutta (Chicago): Intestinal absorption of six tritium labeled digitalis glycosides in rats and guinea pigs. J Pharmacol Exp Ther 167: 265-273, 1969 (no abstract available in PubMed)
104) in german: Ohlmeier H & A.Ruiz-Torres: [Digitoxin and g-strophanthin absorption in the perfused small intestine loop of the rat]. Arzneim-Forsch 22 :1874-76, 1972
105) in german: Forth W, E.Furukawa, W.Rummel & H.Andres: [Determination of the intestinal absorption of cardiac glycosides by measurement of 3H-labelled glycosides in the portal venous blood and in the intestinal lymph of cats] Naunyn-Schmiedebergs Archiv 264 (1969) 406-419, 1969
106) in german: Forth W, E.Furukawa & W.Rummel: [Comparative studies of the absorption and elimination tritium-labelled cardiac glycosides] Naunyn-Schmiedebergs Arch Pharmak 263: 206-208, 1969
107) Marzo A, P.Ghirardi & G.Marchetti: The absorption, distribution and excretion of k-strophanthoside-3H in guinea- pigs afterparenteral administration. J Pharmacol Exp Ther 183: 185-193, 1974
108) Leuschner J& Winkler A (Hamburg): Toxicological studies with ouabain. Naunyn-Schmiedeberg´s Arch Pharmacol 363 Suppl.: 139, abstract 544, 2001(no abstract available in PubMed )
109) in german: Garbe A & H.Nowak: [On the pharmacokinetics of peruvoside. II. Comparative studies with H3-ouabain and H3-digitoxin in guinea pigs] Arzneimittel-Forsch 18: 1597-1601, 1968
110) in german: Forth W, E.Furukawa, W.Rummel & H.Andres: [Intestinal absorption of cardiac glycosides in vitro and in vivo] Naunyn-Schmiedebergs Arch Pharmak Exp Pathol 262: 53-72, 1969
111) in german: Forth W & W.Rummel: [Comparative study of intestinal resorption of 3H-labelled cardiac glycosides in vitro and in vivo] Naunyn-Schmiedebergs Archiv 260: 112-114, 1968
112) in german: Buchtela K, K.Drexler, A.Fehringer, H.Hackl, M.Königstein & J.Schläger: [Resorption, degradation and excretion of acetyldigoxin in animal experiments]. Wien Z Inn Med 51: 227-235, 1970
113) Kitano S, Shigeto Morimoto, Akira Nishibe, Keisuke Fukuo, Atushi Hirotani, Takeshi Nakahashi, Osamu Yasuda & Toshio Ogihara: Exogenous Ouabain is accumulated in the adrenals and mimics the kinetics of endogenous digitalis-like-factor in rats. Hypertens Res 21: 47-56, 1998
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114) in german: Berthold Kern: Zum Nachweis der Strophanthin-Resorption. Medizinische Monatsschrift 6: 371-374, 1952
115) in german: Lendle L, W.Schwerbrock: Über die Wechselwirkungen von g-und k-Strophanthin... Arch Exp Path und Pharmakol 188: 317-327, 1938
116) in german: Fühner H: Rektale Strophanthin-Vergiftung. Der Fall Mertens-Dr.Richter. Dtsch Med Wschr 55: 1408-1409, 1929
117) abstract in english, text in german: Lauterbach F, Günther Vogel & Ingeborg Baumann: [Dependence of the intestinal efficiency rate of cardiac glycosides on the applied dose] Naunyn-Schmiedebergs Arch Pharmak exp Pathol 259: 248-259, 1968 (no abstract available in PubMed)
118) Lauterbach F in Kurt Greeff (ed.): "Handbook of Experimental Pharmacology", Vol. 56/II, 1981
119) Nunez-Duran H, Laura Riboni, Ernestina Ubaldo, Emilio Kabela, & Laura Barcenas-Ruiz: Ouabain uptake by endocytosis in isolated guinea pig atria. J Am Physiol 255: C479-C485, 1988
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120) in german: Erdle HP, K.D.Schultz, E.Wetzel & F.Gross: Resorption und Ausscheidung von g-Strophanthin nach intravenöser und perlingualer Gabe. Dtsch Med Wschr. (Deutsche Medizinische Wochenschrift) 104: 976-979, 1979
121) Marchetti GV, A.Marzo, C.de Ponti, A.Scvalvini, L.Merlo & V.Noseda: Blood levels and tissue distribution of 3H-Ouabain administered per os, Arzneim Forsch (Drug Res) 21: 1399-1403, 1972
(no abstract available in PubMed)
122) Greeff K& K.E.Wirth: Pharmacokinetics of strophantus glykosides, in Kurt Greeff: Handbook of Experimental Pharmacology, Band 56 II : Cardiac Glykosides, S.56-85, Springer B-Hdlbg-N.Y., 1981
123) summary in english: Lahrtz H, R.W.Sattler & P.A.van Zwieten: [On the blood level and secretion of radioactively labeled cardiac glycosides following intraduodenal application in the cat] Z ges exp Med (Zeitschrift für die gesamte experimentelle Medizin) 148: 210-222, 1968 (no abstract available in PubMed)
124) in german: Greeff K, E.Köhler, H.Strobach, E.Verspohl: Zur Pharmakokinetik des g-Strophanthins. Verh Dtsch Ges Kreislaufforschg (Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung) 40: 301-305, 1974
125) in german: Verspohl E: Entwicklung radioimmunologischer Methoden zur Bestimmung von Herzglykosiden des Digitoxigenins, g-Strophanthins und k-Strophantidins mit Untersuchungen zur Pharmakokinetik des Digitoxins und g-Strophanthins. Inaugural-Dissertation, Düsseldorf 1973
126) Strobach H, K.E.Wirth & K.Rojsathaporn: Absorption, metabolism and elimination of strophanthus glycosides in man. Naunyn-Schmiedebergs Arch Pharmacol 334: 496-500, 1986
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127) Riehle M, J.Bereiter-Hahn & B.Boller (Frankfurt/M. / Germany): Effects of ouabain and digitoxin on the respiration of chick embryo cardiomyocytes in culture. Arzneim-Forsch / Drug Res 41: 378-384, 1991
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127 a) Lopatina EV, Penniiaĭnen VA, Tsyrlin VA.: [Comparative analysis of the cardiac glycosides action on the growth of the cardiac tissue explants] article in Russian, abstract in English.
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128) Hamlyn JM, M.P.Blaustein, S.Bova. D.W.DuCharme, D.W.Harris, F.Mandel, W.R.Mathews & J.H.Ludens (Baltimore / USA, Padua / Italy & Kalamazoo / USA): Identification and characterization of a ouabain-like compound from human plasma. Proc Nat Acad Sci USA 88: 259, 1991
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129) Tymiak AA, Norman JA, Bolgar M, DiDonato GC, Lee H, Parker WL, Lo LC, Berova N, Nakanishi K, Haber E et al. (Princeton): Physiochemical characterization of a ouabain isomer isolated from bovine hypothalamus. Proc Nat Acad Sci USA 90:8189-8193, 1993
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130) Zhao N, Lo LC, Berova N, Nakanishi K, Tymiak AA, Ludens JH, Haupert GT Jr. (New York): Na-K-ATPase inhibitors from bovine hypothalamus and human plasma are different from ouabain: nanogram scale CD structural analysis. Biochemistry 34:9893-9896, 1995
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131) Dong JG, Jinsong Guo, I.Akritopoulou-Zanze, Akira Kawamura, Koji Nakanishi & N.Berova (New York): Theoretical and experimental CD of conformationally flexible complex molecules: application to ouabain pentanaphtoate and analogs. Chirality, 11: 707-721, 1999
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132) Kawamura A, Guo J, Itagaki Y, Bell C, Wang Y, Haupert GT Jr, Magil S, Gallagher RT, Berova N, Nakanishi K.(New York): On the structure of endogenous ouabain. Biochemistry 96:6654-6659, 1999
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133) Schneider R, Wray V, Nimtz M, Lehmann WD, Kirch U, Antolovic R, Schoner W. (Giessen): Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. J Biol Chem 273:784-792, 1998
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134) Komiyama Y, Nishimura N, Dong XH, Hirose S, Kosaka C, Masaki H, Masuda M, Takahashi H (Morigucji / Japan): Liquid chromatography mass spectrometric analysis of ouabainlike factor in biological fluid. Hypertens Res 23 (Suppl):S21-S27, 2000
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135) Hamlyn, John M., James Laredo, Jui R. Shah, Zhuo Ren Lu & Bruce P.Hamilton : 11-Hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. Ann N.Y. Acad Sci 986 : 685-693, 2003
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136) Kramer HJ, Krampitz G, Backer A, Meyer-Lehnert H.(Bonn / Germany): Ouabain-like factors in human urine: identification of a Na-K-ATPase inhibitor as Vanadium-Diascorbate adduct. Clin Exp Hypert 20: 557-571, 1998
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137) Li S, Eim C, Kirch U, Lang RE, Schoner W. (Giessen / Germany): Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities. Life Sci 62:1023-33, 1998
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138) Qazzaz HM, Valdes R Jr. (Louisville / USA): Simultaneous isolation of endogenous digoxin-like immunoreactive factor, ouabain-like factor, and deglycosylated congeners from mammalian tissues. Arch Biochem Biophys. 328: 193-200, 1996
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139) Doris PA(Houston (Texas) / USA): Ouabain in plasma from spontaneously hypertensive rats. Am J Physiol 266: H360- H364, 1994
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140) Lewis LK, Tim G.Yandle, John G.Lewis, A.Mark Richards, Grant B.Pidgeon, Risto J.Kaaja & M.Gary Nicholls (Christchurch / Neuseeland) Ouabain is not detectable in human plasma. Hypertension 24: 549-555, 1994
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141) Yamada K, A.Goto & M.Omata (Tokio): Adrenocorticotropin-induced hypertension in rats: role of ouabain-like compound. Am J Hypertens 10: 403-408, 1997
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142) Komiyama Y, Y.Kimura, N.Nishimura, K.Hara, T.Mori, K.Okuda, M.Munakata, M.Masuda, T.Murakami & H.Takahashi (Osaka / Japan): Vasodepressor effects of exercise are accompanied by reduced circulating ouabainlike immunoreactivity and normalization of nitric oxide synthesis. Clin Exp Hypertens 19: 363-72, 1997
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143) Lichtstein D, Michael Steinitz, Irith Gati, Sarah Samuelov, Joseph Deutsch & Joseph Orly (Jerusalem): Biosynthesis of digitalis-like compounds in rat adrenal cells. Life Sci 62: 2109-2126, 1998
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144) Doris PA, Leigh Ann Jenkins & Douglas M.Stocco: Is Ouabain an authentic endogenous mammalian substance derived from the adrenal ? Hypertension 23: 632-638, 1994
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145) Ferrandi M, P.Manunta, S.Balzan, J.M.Hamlyn, G.Bianchi & P.Ferrari (Mailand & Baltimore / USA): Ouabainlike factor quantification in mammalian tissues and plasma: comparison of two independent assays. Hypertension 30: 886, 1997
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146) Shaik IM, B.W.Lau, B.A.Siegfried & R.Valdes Jr (Kentucky / USA): Isolation of digoxin-like immunoreactive factors from mammalian adrenal cortex. J Biol Chem 266: 13672-78, 1991
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147) Goto A & Yamada K (Tokio): Purification of endogenous digitalis-like factors from normal human urine. Clin Exp Hypertens 20: 551-556, 1998
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148) Qazzaz HM, El-Masri MA, Valdes R Jr. (Louisville / Kentucky / USA): Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells. Endocrinology 41: 3200-9, 2000
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149) Lichtstein D, I.Gati, S.Samuelov, D.Berson, Y.Rozenman, L.Landau & J.Deutsch (Jerusalem): Identification of digitalis-like compounds in human cataractous lenses. Eur J Biochem 216: 261-268, 1993
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150) AlexeBagrov AY, Olga V.Fedorova, Renata I.Dmitrieva, William N Howald, Ann P. Hunter, Elena A.Kuznetsova, Vladimir M.Shpen (St.Petersburg): Characterization of a urinary bufodienolide Na-K-ATPase inhibitor in patients after acute myocardial infarction. Hypertension 31: 1097-1103, 1998
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151) Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H.(Osaka):. A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin Biochem.38(1):36-45, 2005
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152) Graves SW, K.E.Markides & N.K.Hollenberg (Provo / USA): Application of supercritical fluid chromatography to characterize a labile digitalis-like factor. Hypertension 2000, 36(6): 1059-1064
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153) Qazzaz HM & Valdes jr. R(Louisville (Kentucky) / USA): Simultaneous isolation of endogenous digoxin-like immunoreactive factor, ouabain-like factor, and deglycosylated congeners from mammalian tissues. Arch Biochem Biophys 328: 193-200, 1996
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154) R.Antolovic, H.Kost, M.Mohadjerani, D.Linder, M.Linder & W.Schoner (Gießen): A specific binding protein for cardiac glycosides exists in bovine serum. J Biol Chem 273: 16259-16264. 1998
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155) Schoner W(Gießen): Ouabain, a new steroid hormone of adrenal gland and hypothalamus. Exp Clin Endocrinol Diabetes 108: 449-454, 2000
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156) Woolfson RG, Poston L: Effect of ouabain on endothelium-dependent relaxation of human resistance arteries. Hypertension 17:619-625, 1991 (the study shows the enganced reaction to NO even when the abstract doesn´t cite exactly)
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157) Woolfson RG, Nicholas T.Richards & Lucilla Poston (London): Low-concentration ouabain does not inhibit noradrenaline-induced contraction of human resistance arteries. Clin Sci 81: 525-529, 1991
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158) Nelissen-Vrancken G, Ju-Feng Wang, Harry A.J.Struijker Boudier, Regien G.Schoemaker, Jos S.F.Smits (Maastricht / Nederlands): Ouabain improves cardiac functionin vivo in rats with heart failure after chronic but not acute treatment. Naunyn-Schmiedebergs Arch Pharmacol 356: 203-209, 1997
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159) Wang J, Aldo Tempini, Bruno Schnyder and Jean-Pierre Montani (Fribourg / Schweiz): Regulation of blood pressure during long-term ouabain infusion in Long-Evans rats. Am J Hypertens 12: 423-426, 1999
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160) Li M, Allison Martin, Cheng Wen, Steven W.Turner & Lynley K.Lewis, Judith A.Witworth (University of New South Wales / Australien & Christchurch / Neuseeland): Long term ouabain administration does not alter blood pressure in conscious Sprague-Dawley rats. Clin Exp Pharmacol Physiol 22: 919-923, 1995
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161) Cargnelli G, Lucia Trevesi, Patrizia Debretto, Sisto Luciani & Sergio Bova (Padua): Effect of long-term ouabain treatment on contractile response of rat aortae. J Cardiovasc Pharmacol 35: 538-542, 2000
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162) Manunta P, A.C.Rogowski, B.P.Hamilton, J.M.Hamlyn (Baltimore / USA): Ouabain induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure. J Hypertens 12: 549-560, 1994
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163) Tamura M, H.Utsunomiya, M.Nakamura & E.J.Landon (Nashville / USA): Effect of dietary glycosides on blood pressure regulation in rats: Can J Physiol Pharmacol 78(7): 548-56, 2000
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164) Yuan CM, Paolo Manunta, John M.Hamlyn, Shanwan Chen, Erin Bohen, Jane Yeun, Francis J.Haddy & Motilal B.Pamnani (Bethesda, Washington, Baltimore / USA): Long-term ouabain administration produces hypertension in rats. Hypertension 22: 178-187, 1993
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165) in german: Kuschinsky G: Die Verhütung von Erschöpfungszuständen des Herzens. Klin Wschr 24/25 (1947) 502-503
166) personal communication, J.M. Hamlyn to an employee of the manufacturing firm of Strodival®, the oral ouabain medicament, BRAHMS Arzneimittel GmbH, Wiesbaden (nowadays MEDA GmbH ,Wiesbaden), at the 65th birthday of Prof. W. Schoner in Giessen 1999
167). Gottlieb S, A.S.Rogowski, M.Weinberg, C.M.Krichten, B.P.Hamilton & J.M.Hamlyn (Baltimore / USA): Elevated concentrations of endogenous ouabain in patients with congestive heart failure. Circulation 86: 420, 1992
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168) Rossi GP, P.Manunta, J.M.Hamlyn, E.Pavan, R.De Toni, A.Semplicini & A.C.Pessina (Padua / Italy): Immuno-reative endogenous ouabain in primary aldosteronism and essential hypertension. J Hypertens 13: 1181-1191, 1995
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169) Manunta P, P.Stella, R.Rivera, D.Ciurlino, D.Cusi, M.Ferrandi, J.M.Hamlyn & G.Bianchi (Milan / Italy)): Left ventricular mass, stroke volume and ouabain-like factor in essential hypertension. Hypertension 34: 450-456, 1999
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170) Wang JG, Staessen JA, Messaggio E, Nawrot T, Fagard R, Hamlyn JM, Bianchi G, Manunta P. (Leuven / Belgium): Salt, endogenous ouabain and blood pressure interactions in the general population. J Hypertens 21:1475-81, 2003
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171) Lanzani C, Citterio L, Jankaricova M, Sciarrone MT, Barlassina C, Fattori S, Messaggio E, Serio CD, Zagato L, Cusi D, Hamlyn JM, Stella A, Bianchi G, Manunta P. (Milan / Italy & Baltimore / USA): Role of the adducin family genes in human essential hypertension. J Hypertens. 23(3):543-549, 2005
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172) Manunta P, Messaggio E, Ballabeni C, Sciarrone MT, Lanzani C, Ferrandi M, Hamlyn JM, Cusi D, Galletti F, Bianchi G; Salt Sensitivity Study Group of the Italian Society of Hypertension.: Plasma ouabain-like factor during acute and chronic changes of sodium balance in essential hypertension. Hypertension 38: 198-203 (2001).
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173) de Wardener HE: Ouabain and hypertension. Nephrol Dial Transplant 12: 384-385, 1997 (no abstract available at Pubmed)
174) Buckalew Jr. VM & Gonick HC(Winston-Salem / USA) : Summary of a symposium on natriuretic and digitalis-like factors. Clin Exp Hypertens 20: 481-488, 1998
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175) Wechter WJ & Murray Jr. ED: Has the elusive "natriuretic factor" been discovered, and if so, is it an hormone? Exp Nephrol 6: 488-490, 1998
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176) Fedorova OV, Talan MI, Agalakova NI, Lakatta EG, Bagrov AY. (Baltimore / USA): Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension. Circulation 105:1122-7 (2002)
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177) D'Urso G, Frascarelli S, Balzan S, Zucchi R, Montali U: Production of ouabain-like factor in normal and ischemic rat heart. J Cardiovasc Pharmacol 43(5):657-62. 2004
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178) Angelis C & Haupert Jr. GT (Rom & Harvard University, Boston / USA): Hypoxia triggers release of an endogenous inhibitor of Na-K-ATPase from midbrain and adrenal. Am J Physiol 274: F182-F188, 1998
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